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Changes in the proportions of types I and III collagen in hemorrhoids: the sliding anal lining theory. This study aims to determine changes in the proportions of types I and III collagen in hemorrhoids and to verify the sliding anal canal lining theory. The study is focused on a sample of 17 patients, 9 females and 8 males age range: 30—70 years , with grade III and grade IV hemorrhoids. Tissue from 4 fetuses age: 16 weeks of gestation was used as control sample. All the participants gave their informed consent. Samples were gathered in All patients underwent open hemorrhoidectomy by using the technique described by Milligan and Morgan, published in Lancet journal in
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3 anal marked
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3 anal marked
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Internal anal sphincter augmentation for fecal incontinence using injectable silicone biomaterial.

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Internal anal sphincter augmentation for fecal incontinence using injectable silicone biomaterial.

A newly identified myopathy of the internal anal sphincter is described. In the affected family, at least one member from each of five generations had severe proctalgia fugax; onset was usually in the third to fifth decades of life. Three members of the family have been studied in detail.
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This muscle is not amenable to direct surgical repair. Previous preliminary attempts to restore functional continuity have included a cutaneous flap to fill an anal canal defect, and injection therapy using polytetrafluoroethylene, collagen, or autologous fat. Urologists have also used injections of collagen or silicone to enhance bladder neck function. This pilot study aimed to assess the efficacy of single or multiple injections of the silicone-based product Bioplastique for the symptoms of passive fecal incontinence caused by an anatomically disrupted or intact but weak internal anal sphincter. Patients were assessed before and six weeks after treatment by clinical assessment, two-week bowel diary card, anorectal physiologic testing, and endoanal ultrasound.
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